CELL INJURY, INRACELLULAR ACUMULATIONS & NECROSIS

Posted by DAM on January 31, 2012 in Intracellular accumulation | Short Link
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CELL INJURY, INRACELLULAR ACUMULATIONS & NECROSIS

A normal cell is able to handle normal physiologic demands (homeostasis).

More extensive physiologic “stresses” or abnormal stimuli may produce a number of functional and structural alterations known as cellular adaptations e.g. hypertrophy and atrophy.

If limits of adaptive response are exceeded or when adaptation is not possible, a sequence of events follows, termed cell injury, which is reversible up to a certain point, but if the stimulus persists or is severe enough, the cell reaches a point of “no return” and suffers irreversible cell injury and cell death.

The principal patterns of cell death are necrosis and apoptosis.

Other morphologic cellular alterations in response to injury include:

■      Sub-cellular alterations involving cell organelles or the cytoskeleton.

■      Intracellular accumulations of a number of substances e.g proteins, lipids, carbohydrates, pigments, largely due to metabolic derangements in cells.

■      Pathologic calcification, a common consequence of cell and tissue injury.

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One Comment

  • Simo says:

    naenif / September 14, 2011You can get into law school with a broad variety of majors. The only restriction is that it should probably be something involving a good amount of reading and writing, so that they know you are prepared to handle both law school and the Bar exam. You could go that route and get a degree in something like English, philosophy, political science, etc., if that interests you. Another possibility would be something in a science area related to human physiology. Since you would have to learn to understand injuries and talk to a lot of medical professionals in the long run (assuming you still want to be an ambulance chaser by the time you finish law school), understanding the terminology and basic concepts might be useful.Reply

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